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(S,R,S)-AHPC TFA
CAS No. 1631137-51-3
(S,R,S)-AHPC TFA( VH032-NH2 TFA | VHL ligand 1 TFA )
Catalog No. M26954 CAS No. 1631137-51-3
(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 369 | Get Quote |
|
| 10MG | 537 | Get Quote |
|
| 25MG | 876 | Get Quote |
|
| 50MG | 1161 | Get Quote |
|
| 100MG | 1593 | Get Quote |
|
| 500MG | 3195 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name(S,R,S)-AHPC TFA
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NoteResearch use only, not for human use.
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Brief Description(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
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Description(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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In Vitro——
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In Vivo——
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SynonymsVH032-NH2 TFA | VHL ligand 1 TFA
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PathwayOthers
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TargetOther Targets
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RecptorhERG| σ1
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Research Area——
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Indication——
Chemical Information
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CAS Number1631137-51-3
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Formula Weight544.59
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Molecular FormulaC24H31F3N4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
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