(S,R,S)-AHPC TFA

CAS No. 1631137-51-3

(S,R,S)-AHPC TFA ( VH032-NH2 TFA; VHL ligand 1 TFA )

Catalog No. M26954 CAS No. 1631137-51-3

(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 369 Get Quote
10MG 537 Get Quote
25MG 876 Get Quote
50MG 1161 Get Quote
100MG 1593 Get Quote
500MG 3195 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    (S,R,S)-AHPC TFA
  • Note
    Research use only, not for human use.
  • Brief Description
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
  • Description
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
  • Synonyms
    VH032-NH2 TFA; VHL ligand 1 TFA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hERG; σ1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1631137-51-3
  • Formula Weight
    544.6
  • Molecular Formula
    C24H31F3N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
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